Patent · US Active

Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same

US9518108B2 · kind B2 · utility

0Cited by

2References

10Claims

0Family size

Assignee

ESBATech, an Alcon Biomedical Research Unit LLC · CH

Inventors

Kathrin Tissot · Schwanau, DE
Stefan Ewert · Basel, CH
Adrian Auf Der Maur · Bellinzona, CH
Alcide Barberis · Bioggio, CH
Dominik Escher · Kreuzlingen, CH

Key dates

Filing date	Aug 26, 2014
Grant date	Dec 13, 2016
Priority date	—
Expiry date	Nov 12, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.