Compounds and methods for modulating interaction between proteins and target nucleic acids

US9518259B2 · kind B2 · utility

Assignee

• Ionis Pharmaceuticals, Inc. · US

Inventors

• Frank Rigo · Carlsbad, US
• C. Frank Bennett · Carlsbad, US
• Adrian R. Krainer · Huntington Station, US
• Yimin Hua · Los Altos, US

Key dates

• Filing date: Jun 15, 2011
• Grant date: Dec 13, 2016
• Expiry date: Jun 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/33
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA.