Medical device with coating for capturing genetically-altered cells and methods for using same
US9522217B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 2004 |
| Grant date | Dec 20, 2016 |
| Priority date | — |
| Expiry date | Dec 31, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/45
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.