Process for preparing Cinacalcet hydrochloride

US9522869B2 · kind B2 · utility

Assignee

• ZACH SYSTEMS S.P.A. · IT

Inventors

• Nicola Catozzi · Thiene, IT
• Livius Cotarca · Palmanova, IT
• Johnny Foletto · San Bonifacio, IT
• Massimiliano Forcato · Monselice, IT
• Roberto Giovanetti · Schio, IT
• Giorgio Soriato · San Bonifacio, IT
• Massimo Verzini · San Bonifacio, IT

Key dates

• Filing date: Jun 13, 2014
• Grant date: Dec 20, 2016
• Expiry date: Jun 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C305/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I)i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII)wherein Z is chloride or another pharmaceutically acceptable anionic counterion.