Sustained-release lipid pre-concentrate of pharmacologically active substance and pharmaceutical composition comprising the same
US9526787B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 28, 2012 |
| Grant date | Dec 27, 2016 |
| Priority date | — |
| Expiry date | Aug 28, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/0016
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) a phospholipid; and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also, a pharmaceutical composition further comprising a pharmacologically active ingredient plus the pre-concentrate is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.