Pyrrolobenzodiazepines and targeted conjugates

US9526798B2 · kind B2 · utility

Assignees

• SEATTLE GENETICS, INC. · US
• MedImmune Limited · US

Inventors

• Scott Jeffrey · Bothell, US
• Patrick Burke · Bothell, US
• Philip Wilson Howard · London, GB

Key dates

• Filing date: Oct 12, 2012
• Grant date: Dec 27, 2016
• Expiry date: Oct 12, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.