Substituted 1-benzylquinoxalin-2(1H)-one analogs as positive allosteric modulators of muscarinic acetylcholine receptor M1
US9527834B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Apr 28, 2014 |
| Grant date | Dec 27, 2016 |
| Priority date | — |
| Expiry date | Apr 28, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/36
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to substituted 1-benzylquinoxalin-2(1H)-one analogs, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); methods for making the compounds; pharmaceutical compositions; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Exemplary 1-benzylquinoxalin-2(1H)-one compounds include compounds of the following formula:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.