Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof

US9527849B2 · kind B2 · utility

Assignees

• TOPHARMAN SHANGHAI CO., LTD. · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES TOPHARMAN SHANDONG CO., LTD · CN

Inventors

• Jianfeng Li · Qingdao, CN
• Guanghui Tian · 安丰镇, CN
• Zhen Wang · Shanghai, CN
• Jin Suo · Shanghai, CN
• Xiangrui Jiang · Shanghai, CN
• Zheng Liu · Beacon Falls, US
• Xiaojun Yang · Shanghai, CN
• Zhu Xie · Shanghai, CN
• Xianguo Zhao · Shanghai, CN
• Weiliang Zhu · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Jingshan Shen · Shanghai, CN

Key dates

• Filing date: Aug 14, 2012
• Grant date: Dec 27, 2016
• Expiry date: Jan 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.