Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist

US9527850B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Kai Schiemann · Darmstadt, DE
• Wolfgang Staehle · Ingelheim am Rhein, DE
• Michael Busch · Darmstadt, DE
• Dirk Wienke · Darmstadt, DE
• Oliver Poeschke · Wiesbaden, DE
• Christa Burger · Darmstadt, DE

Key dates

• Filing date: Sep 7, 2012
• Grant date: Dec 27, 2016
• Expiry date: Sep 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.