Oxindole compounds carrying a CO-bound spiro substituent and use thereof for treating vasopressin-related diseases

US9527856B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Wilfried Braje · Ludwigshafen, DE
• Hervé Geneste · Schifferstadt, DE
• Wilfried Hornberger · Wiesbaden, DE
• Katja Jantos · Ludwigshafen, DE
• Andreas Kling · Mannheim, DE
• Claudia Krack · Ludwigshafen, DE
• Marcel van Gaalen · Ludwigshafen, DE

Key dates

• Filing date: May 15, 2015
• Grant date: Dec 27, 2016
• Expiry date: May 15, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel substituted oxindole derivatives of formula Iwherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds I and their use for the treatment of vasopressin-related disorders.