Bispecific binding molecules binding to VEGF and ANG2

US9527925B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Andreas GSCHWIND · Ingelheim am Rhein, DE
• Rene Georg OTT · Wien, AT
• Joachim BOUCNEAU · Zevergem, BE
• Marie-Ange Buyse · Merelbeke, BE
• Erik Depla · Laarne, BE

Key dates

• Filing date: Mar 29, 2012
• Grant date: Dec 27, 2016
• Expiry date: Mar 29, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bispecific binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.