Patent · US Active

FGF receptor-activating N-sulfate oligosaccharides, preparation thereof, and therapeutic use thereof

US9527930B2 · kind B2 · utility

0Cited by

4References

8Claims

0Family size

Assignee

Sanofi · FR

Inventors

Philippe Duchaussoy · Toulouse, FR
Pierre Fons · Paris, FR
Alexandre Froidbise · Gardouch, FR

Key dates

Filing date	Feb 9, 2012
Grant date	Dec 27, 2016
Priority date	—
Expiry date	Mar 29, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08B37/0075
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are —OSO3− or hydroxyl groups, R2 is an —O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or —O-alkyl group or a disaccharide having Formula (VII), where R10— is an —O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.