Patent · US Active

Granzyme B protease variants

US9528101B2 · kind B2 · utility

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12Claims

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Assignee

PHARMED ARTIS GmbH · DE

Inventors

Stefan Barth · Jena, DE
Sonja Schiffer · Frechen, DE
Grit Hehmann-Titt · Aachen, DE

Key dates

Filing date	Sep 21, 2012
Grant date	Dec 27, 2016
Priority date	—
Expiry date	Oct 2, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21079
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure provides novel variants of enzymes exhibiting serine protease activity; nucleic acid molecules encoding said proteases, vectors, host cells containing the nucleic acids and methods for preparation and producing such enzymes; compositions and complexes comprising at least one of the proteases; and methods for using such enzymes as a part of an immunoprotease, in particular for the treatment of cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.