miRNA fingerprint in the diagnosis of COPD

US9528158B2 · kind B2 · utility

Assignee

• Comprehensive Biomarker Center GmbH · DE

Inventors

• Andreas Keller · Ettlingen, DE
• Eckart Meese · Hütschenhausen, DE
• Anne Borries · Heidelberg, DE
• Markus Beier · Heidelberg, DE

Key dates

• Filing date: Jun 30, 2015
• Grant date: Dec 27, 2016
• Expiry date: Jun 30, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/178
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.