Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device
US9528968B2 · kind B2 · utility
7Cited by
1References
21Claims
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Key dates
| Filing date | Oct 13, 2015 |
| Grant date | Dec 27, 2016 |
| Priority date | — |
| Expiry date | Oct 13, 2035 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/167
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.