Development and use of fluorescent probes of unbound bilirubin
US9529003B2 · kind B2 · utility
1Cited by
2References
45Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2012 |
| Grant date | Dec 27, 2016 |
| Priority date | — |
| Expiry date | Nov 2, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/146666
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Identification and use of proteins fluorescently labeled and that undergo a change in fluorescence index upon binding bilirubin are described. Probes are disclosed which are labeled at a cysteine or lysine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for determination of unbound bilirubin levels in a fluid sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.