Compositions and methods for promoting intestinal stem cell function

US9532997B2 · kind B2 · utility

Assignee

• Whitehead Institute For Biomedical Research · US

Inventors

• Pekka Katajisto · Cambridge, US
• Michael Pacold · Boston, US
• David M. Sabatini · Cambridge, US
• Omer Yilmaz · Ann Arbor, US

Key dates

• Filing date: Apr 3, 2013
• Grant date: Jan 3, 2017
• Expiry date: Apr 3, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).