Patent · US Active

Identification of surface-associated antigens for tumor diagnosis and therapy

US9533043B2 · kind B2 · utility

7Cited by

1References

5Claims

0Family size

Assignee

BioNTech AG · DE

Inventors

Ozlem Tureci · Homburg, DE
Ugur Sahin · Mainz, DE
Sandra Schneider · Blankenloch, DE
Gerd Helftenbein · Mücke, DE
Volker Schlüter · Schwanau, DE
Dirk Usener · Wiesbaden, DE
Philippe Thiel · Planegg, DE
Michael Koslowski · Mainz, DE

Key dates

Filing date	Sep 25, 2013
Grant date	Jan 3, 2017
Priority date	—
Expiry date	Aug 24, 2034

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/53
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.