Drug loaded microfiber sutures for ophthalmic application

US9533068B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Fabiana Kimie Kashiwabuchi · Baltimore, US
• Justin Hanes · Baltimore, US
• Hai-Quan Mao · Singapore, SG
• Peter J. McDonnell · Baltimore, US
• Qingguo Xu · Glen Allen, US
• Shuming Zhang · Presbyterian Villas Of Lehigh, US

Key dates

• Filing date: May 6, 2013
• Grant date: Jan 3, 2017
• Expiry date: Aug 14, 2033

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29L2031/7546
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(l-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.