Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)
US9533973B2 · kind B2 · utility
1Cited by
7References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 7, 2012 |
| Grant date | Jan 3, 2017 |
| Priority date | — |
| Expiry date | Dec 7, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.