Pyridine derivatives

US9533981B2 · kind B2 · utility

Assignee

• Asana BioSciences, LLC · US

Inventors

• Roger Smith · Madison, US
• Nicholas James Laping · Malvern, US
• Aranapakam Venkatesan · Chadds Ford, US
• Raghava Reddy Kethiri · Noida, IN
• Chandregowda Venkateshappa · Noida, IN
• Bheemashankar A. Kulkarni · Noida, IN
• Purushottam Dewang · Kanchinakote, IN
• Rajendra Kristam · Noida, IN
• Rajesh Devraj · Chesterfield, US

Key dates

• Filing date: Nov 13, 2013
• Grant date: Jan 3, 2017
• Expiry date: Nov 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CYP17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.