Patent · US Active

Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof

US9533995B2 · kind B2 · utility

0Cited by
13References
8Claims
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Assignee

Inventors

Key dates

Filing dateJun 27, 2014
Grant dateJan 3, 2017
Priority date—
Expiry dateOct 22, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D471/10
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure relates to a series of substituted N-heteroaryl spirolactam bipyrrolidines of formula (I).Wherein R1, R2, Q1, Q2, Q3, Q4, X, m, n, p and s are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-heteroaryl spirolactam bipyrrolidines of formula (I) and intermediates therefor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.