Patent · US Active

Method for the production of immunoglobulin single variable domains

US9534039B2 · kind B2 · utility

3Cited by

0References

22Claims

0Family size

Assignee

Ablynx N.V. · BE

Inventors

Ann Brigé · Ertvelde, BE
Peter Schotte · Zevergem, BE
Bart Walcarius · Gentbrugge, BE

Key dates

Filing date	May 9, 2012
Grant date	Jan 3, 2017
Priority date	—
Expiry date	Mar 25, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P21/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of homogeneous immunoglobulin variable domains in which the proportion of product-related variants that comprise, at the N-terminus, at least one redundant amino acid residue derived from the secretion signal is strongly reduced or absent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.