Patent · US Active

Methods, compositions, and kits for detecting allelic variants

US9534255B2 · kind B2 · utility

4Cited by
43References
61Claims
0Family size

Assignee

Inventors

Key dates

Filing dateDec 17, 2009
Grant dateJan 3, 2017
Priority date—
Expiry dateJun 4, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/172
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.