Method for manufacturing phosphonocrotonic acid derivative
US9540301B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 26, 2012 |
| Grant date | Jan 10, 2017 |
| Priority date | — |
| Expiry date | Mar 25, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4015
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative.The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base.[in the formula, R1 represents a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkenyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkynyl group that may be substituted by a C6-10 aryl group, or a C6-10 aryl group, R2 represents a hydrogen atom, or a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, R3 represents a C1-6 linear or branched alkyl group, a C6-10 aryl group, or a halogen atom, and X represents a halogen atom, and multiple R1s may be the same or different].
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.