Hexahydrodiazepinoquinolines carrying a substituted alkyl radical

US9540376B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Gisela Backfisch · Dossenheim, DE
• Margaretha Henrica Maria Bakker · Ludwigshafen, DE
• Günter BLAICH · Ludwigshafen, DE
• Wilfried Braje · Ludwigshafen, DE
• Karla Drescher · Ludwigshafen, DE
• Thomas ERHARD · Ludwigshafen, DE
• Andreas Haupt · Ludwigshafen, DE
• Viktor Lakics · Budapest, HU
• Anna LINSENMEIER · Ludwigshafen, DE
• Helmut Mack · Ludwigshafen, DE
• Raimund PETER · Wilmslow, GB
• Ana-Lucia Relo · Ludwigshafen, DE
• Lynette Smyth · Ludwigshafen, DE

Key dates

• Filing date: Mar 13, 2015
• Grant date: Jan 10, 2017
• Expiry date: Mar 13, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to tricyclic hexahydrodiazepinoquinolines, such as compounds of formula (I), carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.