Patent · US Active

Method for monofluoromethylation of organic substrates to prepare biologically active organic compounds

US9540413B2 · kind B2 · utility

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3References
12Claims
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Key dates

Filing dateJun 1, 2011
Grant dateJan 10, 2017
Priority date—
Expiry dateJan 29, 2033

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07J31/006
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Described herein is a process for the preparation of monofluoromethylated organic biologically active compounds using monofluoromethylated reagents. Fluticasone Propionate and Fluticasone Furoate can be prepared using, for example, S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate as monofluoromethylating reagent instead of bromofluoromethane.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.