Methods for programming differentiated cells into hematopoietic stem cells

US9540612B2 · kind B2 · utility

Assignee

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US

Inventors

• Ihor R. Lemischka · Princeton, US
• Kateri Moore · Princeton, US
• Carlos Filipe Ribeiro Lemos Pereira · New York, US

Key dates

• Filing date: Jan 30, 2013
• Grant date: Jan 10, 2017
• Expiry date: Jan 30, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.