Vector comprising multiple homologous nucleotide sequences
US9540660B2 · kind B2 · utility
0Cited by
5References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 9, 2015 |
| Grant date | Jan 10, 2017 |
| Priority date | — |
| Expiry date | Mar 9, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.