NMR quantification of TMAO

US9541620B2 · kind B2 · utility

Assignee

• LipoScience, Inc. · US

Inventors

• James D. Otvos · Apex, US
• Elias J. Jeyarajah · Raleigh, US
• Justyna E. Wolak-Dinsmore · Durham, US
• Thomas M. O'Connell · Chapel Hill, US
• Dennis W. Bennett · Shorewood, US
• Steven P. Matyus · Durham, US
• Stanley L. Hazen · Pepper Pike, US

Key dates

• Filing date: May 16, 2013
• Grant date: Jan 10, 2017
• Expiry date: May 16, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/323
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A defined peak region residing between about 3.2 and 3.4 ppm of a proton NMR spectrum of an in vitro biosample is electronically evaluated to determine a level of trimethylamine-N-oxide (“TMAO”). The biosamples may be any suitable biosamples including human serum with a normal biologic range of between about 1-50 μM or urine with a normal biologic range of between about 0-1000 μM.