Methods of increasing efficiency of vector penetration of target tissue
US9546112B2 · kind B2 · utility
34Cited by
1References
2Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 22, 2011 |
| Grant date | Jan 17, 2017 |
| Priority date | — |
| Expiry date | Mar 23, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/6027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.