Compositions, antibodies, asthma diagnosis methods, and methods for preparing antibodies
US9546220B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2011 |
| Grant date | Jan 17, 2017 |
| Priority date | — |
| Expiry date | Oct 19, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/122
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for preparing an antibody are provided with the method including incorporating 3-bromo-4-hydroxy-benzoic acid into a protein to form an antigen, immunizing a mammalian host with the antigen, and recovering an antibody having an affinity for the antigen from the host. Antibodies having a binding affinity for a monohalotyrosine are provided as well as composition comprising an antibody bound with monohalotyrosine. Compositions comprising a protein having a 3-bromo-4-hydroxy-benzoic acid moiety are also provided. Methods for evaluating the severity of asthma are provide with the methods including analyzing sputum of a patient using an antibody having a binding affinity for monohalotyrosine, and measuring the amount of antibody bound to protein. Methods for determining eosinophil activity in bodily fluid are also provided with the methods including exposing bodily fluid to an antibody having a binding affinity for monohalotyrosine, and measuring the amount of bound antibody to determine the eosinophil activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.