Patent · US Active

Multicistronic expression constructs

US9546369B2 · kind B2 · utility

59Cited by

33References

23Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Guangping Gao · Rosemont, US
Jun Xie · Singapore, SG

Key dates

Filing date	Apr 22, 2011
Grant date	Jan 17, 2017
Priority date	—
Expiry date	Aug 3, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/42
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Some aspects of this invention provide nucleic acid constructs for transgene expression. Some aspects of this invention provide multicistronic nucleic acid constructs, for example, comprising an expression cassette encoding a hairpin RNA and a reporter expression cassette. Some aspects of this invention provide nucleic acid constructs comprising two or more self-complementary nucleic acid sequences, for example, hairpin RNA encoding nucleic acid sequences and AAV inverse terminal repeats. Methods for the use of the constructs in therapy and research are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.