Chimeric polynucleotides and polypeptides enabling secretion of a polypeptide of interest in association with exosomes and use thereof for the production of immunogenic compositions
US9546371B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 18, 2009 |
| Grant date | Jan 17, 2017 |
| Priority date | — |
| Expiry date | Apr 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/14022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns a chimeric polypeptide comprising several polypeptide domains, which is capable of being secreted in association with membrane vesicles and in particular exosomes.The present invention also concerns a polypeptide constituted by one of said domains for the secretion of a peptide or polypeptide of interest in association with membrane vesicles and in particular exosomes.The invention also concerns the use of polypeptides of the invention and of polynucleotides coding for said polypeptides for the production of immunogenic compositions based on exosomes or based on DNA or for screening protein interactions.The present invention also concerns exploiting the properties of exosomes comprising a polypeptide of the invention and of immunogenic compositions of the invention for the prophylaxis and/or treatment of an infection by a pathogenic agent, a pathogenic organism, a tumour antigen or a cytoplasmic antigen, in particular to elicit or promote, in vivo, in a host, in particular in a human or non-human mammal or a bird, a humoral and/or cellular response against a virus, bacterium, parasite or tumour.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.