Automated MRI detection of tissue macromolecular T2/T2* characteristics using Z-spectra
US9547058B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 31, 2012 |
| Grant date | Jan 17, 2017 |
| Priority date | — |
| Expiry date | Nov 19, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/5605
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A magnetic resonance imaging (MRI) system and method (a) acquires k-space data for a patient ROI over a predetermined band of RF frequencies using RF excitation pulses having respectively corresponding RF frequencies incrementally offset from a nuclear magnetic resonant (NMR) Larmor frequency for free nuclei thus causing chemical exchange saturation transfer (CEST) effects and to process such acquired data into Z-spectra data for voxels in the ROI; (b) analyzes the acquired Z-spectra data to provide spectral peak width data corresponding to T2/T2* tissue values in the ROI for macromolecules participating in magnetization transfer contrast (MTC) effects producing said Z-spectra data; and (c) stores and/or displays data representative of T2/T2* tissue values of the ROI which values are different for different tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.