Method for determining fetal chromosomal abnormality
US9547748B2 · kind B2 · utility
0Cited by
7References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2011 |
| Grant date | Jan 17, 2017 |
| Priority date | — |
| Expiry date | Jun 29, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.