Chelated nanoceria for the treatment of oxidative stress
US9549950B2 · kind B2 · utility
1Cited by
3References
13Claims
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Key dates
| Filing date | Apr 25, 2014 |
| Grant date | Jan 24, 2017 |
| Priority date | — |
| Expiry date | Aug 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC01P2006/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.