Diagnosis, prognosis, and treatment of kidney disease
US9549964B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 13, 2012 |
| Grant date | Jan 24, 2017 |
| Priority date | — |
| Expiry date | Oct 8, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.