Compositions, methods of synthesis and use of carbohydrate targeted agents
US9550001B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 20, 2012 |
| Grant date | Jan 24, 2017 |
| Priority date | — |
| Expiry date | Dec 16, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0482
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides D02S derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein the D02S derivatives having the following structure: wherein R1′, R2′ are each independently —OH or —O-alkyl; R1 is a hydrogen, a linker, or a ligand; R3 is a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a GLUT1 targeting moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.