Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines

US9550773B2 · kind B2 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• Doris Stoermer · White Bear Lake, US
• Joseph F. Dellaria · Woodbury, US
• David T. Amos · Windom, US
• Bernhard M. Zimmermann · Saint Paul, US
• Luke T. Dressel · Somerset, US
• Jason D. Bonk · Hudson, US
• Matthew R. Radmer · Robbinsdale, US

Key dates

• Filing date: Apr 13, 2015
• Grant date: Jan 24, 2017
• Expiry date: Apr 13, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.