Humanized anti-HMGB1 antibody or antigen-binding fragment thereof
US9550825B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Dec 6, 2013 |
| Grant date | Jan 24, 2017 |
| Priority date | — |
| Expiry date | Dec 6, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.