Automated dilution for liquid chromatography
US9551329B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2010 |
| Grant date | Jan 24, 2017 |
| Priority date | — |
| Expiry date | Feb 17, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/20
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.