High throughput biochemical detection using single molecule fingerprinting arrays

US9551682B2 · kind B2 · utility

Assignee

• Intel Corporation · US

Inventors

• Oguz H. Elibol · Sunnyvale, US
• Grace Credo · San Mateo, US
• Xing Su · Cupertino, US
• Madoo Varma · Palo Alto, US
• Jonathan S. Daniels · Palo Alto, US
• Drew Hall · Village of La Jolla, US
• Handong Li · San Jose, US
• Noureddine Tayebi · Menlo Park, US
• Kai Wu · Mountain View, US

Key dates

• Filing date: Jun 29, 2012
• Grant date: Jan 24, 2017
• Expiry date: Aug 13, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B50/16
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.