Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids

US9551706B2 · kind B2 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• Scott T. Phillips · Cambridge, US
• George M. Whitesides · Newton, US
• Katherine A. Mirica · Hanover, US
• Emanuel Carrilho · Sharon, US
• Andres W. Martinez · Cambridge, US
• Sergey S. Shevkoplyas · Friendswood, US
• Phillip W. Snyder · White House, US
• Raquel Perez-Castillejos · Cambridge, US
• Malancha Gupta · Cambridge, US
• Adam Winkleman · Brookline, US
• Katherine L. Gudiksen · San Francisco, US

Key dates

• Filing date: Jun 30, 2008
• Grant date: Jan 24, 2017
• Expiry date: Nov 30, 2031

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0487
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.