Multi-layered micro-channel electrode array with regenerative selectivity
US9555235B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 26, 2015 |
| Grant date | Jan 31, 2017 |
| Priority date | — |
| Expiry date | Jun 14, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/36003
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.