Phosphatidylcholine transfer protein inhibitors

US9556129B2 · kind B2 · utility

Assignee

• The Brigham and Women's Hospital, Inc. · US

Inventors

• David Cohen · Sharon, US
• Neil Wagle · Brookline, US
• Gregory D. Cuny · Houston, US
• Jun Xian · Sharon, US
• Marcie Glicksman · Salem, US
• Ross L. Stein · Sudbury, US
• Ekaterina Y. Shishova · Via Enrico Fermi, US

Key dates

• Filing date: Jul 29, 2015
• Grant date: Jan 31, 2017
• Expiry date: Jul 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.