Process for the preparation of (R,S)-nicotine
US9556142B2 · kind B2 · utility
10Cited by
2References
20Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 22, 2015 |
| Grant date | Jan 31, 2017 |
| Priority date | — |
| Expiry date | Oct 22, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of preparing (R,S)-nicotine, comprising reacting a nicotinate ester with N-vinyl-2-pyrrolidinone in the presence of a base and a solvent to form a first mixture, combining the first mixture with an acid to form a second mixture comprising an aqueous layer, separating the aqueous layer from second mixture, combining the separated aqueous layer with an acid to form a third mixture, combining the third mixture with a base to form a fourth mixture comprising myosamine, reducing myosamine to nornicotine using a reducing agent, and methylating the nornicotine to yield R,S-nicotine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.