Substituted 1,3-thiazoles as synthetic intermediates for preparation of Raf kinase inhibitors

US9556177B2 · kind B2 · utility

Assignees

• Millennium Pharmaceuticals, Inc. · US
• Sunesis Pharmaceuticals, Inc. · US

Inventors

• Weirong Chen · Waltham, US
• Benjamin S. Lane · Chelsea, US
• Hairuo Peng · Needham, US

Key dates

• Filing date: Jul 28, 2014
• Grant date: Jan 31, 2017
• Expiry date: Jul 28, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds having Formula II-vi-a:wherein Cy1, Cy2, and A− are defined as set forth in the specification. These compounds are synthetic intermediates used to prepare inhibitors of Raf protein kinase.