Peptides with antifungal activity and methods of using the peptides

US9556226B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Suresh Kumar Thallapuranam · Fayetteville, US
• David S. McNabb · Fayetteville, US
• Yazan Hussien Akkam · Fayetteville, US
• Duy Nguyen · Berlin, DE

Key dates

• Filing date: Mar 14, 2014
• Grant date: Jan 31, 2017
• Expiry date: Mar 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/4723
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1 and variations thereof. The peptides may contain L or D amino acids and may be circularized, dimerized or otherwise modified to make the compositions resistant to proteolysis. The compositions may be used to inhibit microbial growth and in particular fungal growth.