Patent · US Active

Template-fixed peptidomimetics

US9556234B2 · kind B2 · utility

4Cited by

14References

3Claims

0Family size

Assignees

POLYPHOR AG · CH
UNIVERSITAET ZUERICH · CH

Inventors

Daniel Obrecht · Amriswil, CH
Frank Gombert · Basel, CH
Steven J. Demarco · Diegten, CH
Christian Ludin · Oberwil, CH
Jan Wim Vrijbloed · Bellinzona, CH
Kerstin Moehle · Wettswil, CH
John Anthony Robinson · Wermatswil, CH
Reshmi Mukherjee · Newton, US
Heiko Henze · Zürich, CH
Barbara Romagnoli · La Valette-du-Var, FR

Key dates

Filing date	Nov 28, 2014
Grant date	Jan 31, 2017
Priority date	—
Expiry date	Nov 28, 2034

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.